How accurate is the Cologuard test? Cologuard can detect 92% of cancers but only 42% of large precancerous polyps. Cologuard is better at detecting cancer than FIT (92% versus 74% for FIT), but the false positive rate is higher. Cologuard has a 13% false-positive rate, and that rate increases as people age.

Cologuard is a screening test for colon and rectal cancer. The colon sheds cells from its lining every day. These cells pass with the stool through the colon. Colon cancer cells may have DNA changes in certain genes. Cologuard detects the altered DNA.

While it is better at detecting cancer than FIT (92% vs 74% for FIT), the false positive rate is higher. The Cologuard false-positive rate is 13%, and that rate increases as people age. Cologuard is less accurate than a colonoscopy at detecting polyps of any size.

A positive result does not necessarily mean a patient has cancer. It means that Cologuard detected DNA and/or hemoglobin biomarkers in the stool that are associated with colorectal cancer or advanced adenoma. False positives and false negatives occur with Cologuard, and appropriate follow-up is important.

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Cologuard is indicated to screen adults of either sex, 45 years or older, who are at typical average risk for CRC. Cologuard is not a replacement for diagnostic colonoscopy or surveillance colonoscopy in high-risk individuals.

Cologuard is a stool-based test and also can be known as the fecal immunochemical test (FIT). These stool-based tests can be done at home have a much higher sensitivity and specificity for colon cancer. Cologuard looks for blood in your stool, precancerous polyps or abnormal DNA.

Exact Sciences Corporation Exact Sciences Corporation provides cancer screening and diagnostic test products in the United States and internationally. The company offers Cologuard, a non-invasive stool-based DNA screening test to detect DNA and hemoglobin biomarkers associated with colorectal cancer and pre-cancer.

Pro – No prep work or anesthesia necessary Cologuard doesn't require the unpleasant bowel preparation, sedation or insertion of a scope that comes with a colonoscopy. Patients can eat and drink normally before they collect the stool sample at home, avoiding disruption of work and daily activities.

Cologuard is indicated to screen adults of either sex, 45 years or older, who are at typical average-risk for CRC. Cologuard is not a replacement for diagnostic colonoscopy or surveillance colonoscopy in high risk individuals.

Next-generation Cologuard Test Demonstrates 94 Percent Sensitivity for Colorectal Cancer at 91 Percent Specificity, Raising the Bar in Non-invasive Screening.

The test is done to screen for colon and rectal cancer and abnormal growths (polyps) in the colon or rectum. Your provider may suggest Cologuard testing once every 3 years after age 50 years. The test is recommended if you are between ages 50 to 75 years and have an average risk of colon cancer.