What is HUMIRA Citrate-free? HUMIRA Citrate-free is the same as original HUMIRA, but without citrate . buffers, and includes other device enhancements. The latest HUMIRA presentation, Citrate-free, works just like original HUMIRA, but with less pain immediately following injection.

Citrate is a buffer, or a chemical that's used to help maintain the stability of medications, explains James Wu, PharmD, a pharmacist and manager of a Walgreens community pharmacy in Chicago. “It's commonly found in injectable medications such as Humira to help it keep its chemical and physical properties,” he says.

The citrate-free high-concentration formulation (HCF) of adalimumab-adaz (Hyrimoz; Sandoz Inc), a biosimilar injection of adalimumab (Humira; AbbVie), became available in the United States on July 1, according to a Sandoz press release.

No more citrate: Citrate was found to cause pain when Humira® is injected. So along with other inactive ingredients, it has been removed. Even smaller needle: The older version of Humira® had a 27-gauge needle, whereas the new form has a 29-gauge needle.

In pivotal trials, this formulation of the reference Humira was linked with ISRs in 12.9% of patients. Later, AbbVie, maker of the reference drug, reformulated its product to remove the citrate buffer in an effort to reduce both the product's injection volume and the incidence of ISRs.

Yuflyma (adalimumab-aaty, Celltrion USA) is a high-concentration (100 mg/mL), citrate-free biosimilar to the world's top-selling Humira (adalimumab, AbbVie), approved for patients with adult Crohn's disease, ulcerative colitis, rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing ...

What is this medication? SODIUM CITRATE; CITRIC ACID (SOE dee um SIT rate; SIT rik AS id) prevents and treats high acid levels in your body. It may also be used to help prevent gout or kidney stones, conditions caused by high uric acid levels. It works by decreasing the amount of acid in your body.

In the pharmaceutical industry it is used to control pH. It may be used as an alkalizing agent, buffering agent, emulsifier, or sequestering agent.

The FDA approved a citrate-free high-concentration formulation (HCF) of adalimumab-adaz (Hyrimoz, Sandoz) injection, a biosimilar to Humira (AbbVie). The adalimumab citrate-free HCF (100 mg/mL) is approved to treat seven indications covered by the reference biologic, including Crohn's disease and ulcerative colitis.

Inflation rebates were lower for citrate-free Humira, resulting in a significantly higher Medicaid net price. Although there is 1 interchangeable adalimumab biosimilar on the market so far (Cyltezo), more are expected to come, including for Amjevita.

Recent manufacturing problems and increased utilization has created a shortage of 3.2% sodium citrate blood collection tubes used for coagulation testing, causing stakeholders such as hospitals, clinics and laboratories, to find suitable alternatives.

What was the magnesium citrate recall? In 2022, a laxative sold at major retailers across the U.S. issued a voluntary recall of magnesium citrate due to a microbial contamination that was causing adverse reactions in consumers.