Prevagen ® is an OTC brain health supplement clinically shown to be safe and to improve memory and support brain function, such as mild memory loss associated with aging.

Prevagen is a dietary supplement that's advertised to help with mild memory loss.

Apoaequorin Apoaequorin, the active ingredient in Prevagen®, is a calcium-binding protein isolated from jellyfish Aequorea victoria and has been used for many years as a calcium indicator.

Adverse effects of apoaequorin are very rare, but research suggests they can include headache, nausea, constipation, edema and hypertension. Prevagen comes in three formulations - regular strength, extra strength and professional strength - and 30-capsule and 60-capsule quantities.

Treats cognitive symptoms (memory and thinking)

Do over-the-counter supplements help improve memory loss? Basically, no. None of the supplements marketed as being helpful for memory, or helpful in reducing dementia or reducing risk of Alzheimer's disease, has been shown to be effective.

A lab-made version of apoaequorin is the main ingredient in the over-the-counter dietary supplement called Prevagen, which claims to improve mild memory loss linked to aging. If you've thought about trying Prevagen, it's important to get the facts.

Madison, Wisconsin Prevagen® is made by Quincy Bioscience and was developed by scientists and University researchers in Madison, Wisconsin.

Not all vitamins and minerals are crucial for brain health and function. If you're experiencing constant brain fog or you're always tired, it's worth checking your diet for four in particular: vitamin B12, vitamin D, iron and magnesium.

Cholinesterase inhibitors are the first choice of treatment for memory loss. The doctor may also prescribe the single-dose drug combination Namzeric to treat moderate to severe memory loss.

Many memory supplements aren't sold as single ingredients. Though some ingredients might work well together, combined supplements are harder to study and could be risky. Supplements may cause side effects, and the risk rises with the number you take. Mixing them with prescription drugs can be risky, too.

However, as discussed below, there is little evidence that Prevagen (from Quincy Bioscience) provides any meaningful benefit in terms of memory improvement, and the extent of potential improvement appears to be minimal.