Monistat has been studied in clinical trials. Researchers found that the one-day treatment of a vaginal miconazole ovule was safe and effective. Individuals who used the one-day treatment felt better faster than the seven-day treatment with vaginal cream.

Most women get some improvement in 1 day and complete relief by 7 days.

Monistat-1 is a single dose vaginal cream/tablet used to treat a vaginal yeast infection. The cream is designed to stay within the vagina to work without having to reapply every day for seven days. It is normal to get some medicine leakage/discharge.

Insert the tablet or the applicator into the vagina as far as it will comfortably go. Slowly press the plunger of the applicator to release the tablet. If you have itching/burning around the outside of the vagina (vulva), apply the skin cream to that area usually twice a day for no more than 7 days.

Safety First If you have never had a vaginal yeast infection before, see your healthcare professional before using any MONISTAT® antifungal product. Do not use MONISTAT® 1, 3, or 7 day products for external vaginal (vulvar) itching due to causes other than a yeast infection.

All the Monistat products are considered equally safe and effective. They should all provide some relief from symptoms from a yeast infection within 3 days. The best option for you will depend on your preference and how your body reacts to the medications.

The MONISTAT® 1 Ovule® stays in place and can be used day or night, making it a great solution for women who don't want to wait until bedtime to begin treating their yeast infection, or for those who exercise frequently or engage in high levels of activity.

Monistat 1-Day can be used at anytime (day or night) and may be a better option if: You want to start treatment right away. You prefer not to treat for multiple days. You exercise frequently.

Official answer. Most women use Monistat (miconazole) right before bedtime, and then lay down for the rest of the night while sleeping. For best results, lie down as soon as possible after inserting the product. This can help prevent significant leakage.

The MONISTAT® 1 Ovule® stays in place and can be used day or night, making it a great solution for women who don't want to wait until bedtime to begin treating their yeast infection, or for those who exercise frequently or engage in high levels of activity.

Should I use Monistat 1, 3, or 7? All the Monistat products are considered equally safe and effective. They should all provide some relief from symptoms from a yeast infection within 3 days. The best option for you will depend on your preference and how your body reacts to the medications.

Headache or vaginal/urethral burning/itching/pain may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. If your doctor has prescribed this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects.