Premarin is used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women. Premarin is also used to replace estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body.

As the cream is spread, some may be gently inserted into the vagina: however, it is not necessary to push the cream high into the vagina. Rub this into the vaginal wall underneath the urethra as one would rub lotion into the skin.

PREMARIN Vaginal Cream is administered intravaginally in a cyclic regimen (daily for 21 days and then off for 7 days). Generally, women should be started at the 0.5 g dosage strength. Dosage adjustments (0.5 to 2 g) may be made based on individual response [see Dosage Forms and Strengths (3)].

Some women may stay on hormones for two or three years, while others will need five to seven years, or maybe longer. The goal is to be on the lowest dose that will treat and manage your symptoms in such a way that the benefits outweigh the risks.

Check with your health care professional to make sure the vaginal estrogen product you are using can be used with latex devices. This medicine is often used at bedtime to increase effectiveness through better absorption. Vaginal creams or suppositories will melt and leak out of the vagina.

PREMARIN Vaginal Cream is administered intravaginally in a cyclic regimen (daily for 21 days and then off for 7 days). Generally, women should be started at the 0.5 g dosage strength. Dosage adjustments (0.5 to 2 g) may be made based on individual response [see Dosage Forms and Strengths (3)].

The most likely risk is that your menopausal symptoms return. Some research also suggests a rise in blood pressure and a slight increase in risk of heart attack or stroke in the year after stopping HRT. But overall, the risks of stopping HRT are low. And you can do it in a slow, comfortable, and safe way.

Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots. Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.

To treat moderate to severe painful intercourse, a symptom of vulvar and vaginal atrophy (VVA) due to menopause, 0.5 g of Premarin Vaginal Cream can be applied twice a week or in a cyclic regimen of 21 days of therapy followed by 7 days off therapy.

Some women may stay on hormones for two or three years, while others will need five to seven years, or maybe longer. The goal is to be on the lowest dose that will treat and manage your symptoms in such a way that the benefits outweigh the risks.

To treat moderate to severe painful intercourse, a symptom of vulvar and vaginal atrophy (VVA) due to menopause, 0.5 g of Premarin Vaginal Cream can be applied twice a week or in a cyclic regimen of 21 days of therapy followed by 7 days off therapy.

Generally, Premarin should be used at the lowest possible dose for the shortest amount of time necessary. This can be different for every woman. But the longer Premarin is taken, the more risk there is for serious side effects to happen.

How much should I use? Your doctor will prescribe the dosage that's right for you. Estrogens, with or without a progestin, should be used at the lowest effective dose for the shortest duration of time. A single tube of Premarin Vaginal Cream can last up to 6 months depending on the dosing regimen prescribed.

PREMARIN Vaginal Cream is administered intravaginally in a cyclic regimen (daily for 21 days and then off for 7 days). Generally, women should be started at the 0.5 g dosage strength. Dosage adjustments (0.5 to 2 g) may be made based on individual response [see Dosage Forms and Strengths (3)].

The Women's Health Initiative (WHI) was a nationwide study that looked for common causes of death in women after menopause. The WHI found an increased risk of blood clots, stroke, or heart attack in people taking Premarin plus a progestin. And an increased risk of stroke when Premarin was used alone.