What is Repatha?
Repatha (evolocumab) is a prescription drug used in adults with cardiovascular disease to help reduce the risk of heart attack , stroke, and certain types of heart surgeries. It is a PCSK9 inhibitor that works by blocking a particular protein that increases the level of low-density lipoprotein (LDL) cholesterol in the blood. Repatha is administered through injection and is usually given once every two weeks.
Repatha was initially approved by the U.S. Food and Drug Administration (FDA) in 2015 , and it is generally safe and effective for the treatment of high cholesterol levels, especially in patients with familial hypercholesterolemia. It can be self-administered with the SureClick or Pushtronex delivery systems, or with the help of healthcare professionals.
The recommended dosage of Repatha is either 140 mg every two weeks or 420 mg once per month. However, the dosage may vary depending on individual patient needs. Possible side effects of Repatha include itching, swelling, or bruising at the injection site, headache, and muscle pain. Serious side effects are rare, but may include allergic reactions, confusion, and liver problems.
Overall, Repatha can be a helpful tool in managing high cholesterol and reducing the risk of heart-related events, but as with any medication, it is important to talk to your doctor about the potential benefits and risks of using Repatha.
Frequently Asked Questions about repatha
Repatha ® enhances removal of LDL-cholesterol
By inhibiting PCSK9, Repatha ® increases the number of LDL-C receptors on the surface of the liver, resulting in reduction of LDL-C from circulation.
The active substance is evolocumab. Each SureClick pre-filled pen contains 140 mg of evolocumab in 1 mL of solution. The other ingredients are proline, glacial acetic acid, polysorbate 80, sodium hydroxide, water for injections.
How does Repatha work? The active substance in Repatha, evolocumab, is a monoclonal antibody (a type of protein) that has been designed to attach to a protein called PCSK9. PCSK9 attaches to cholesterol receptors on the surface of liver cells, causing the receptors to be absorbed and broken down inside the cells.
Repatha ® (evolocumab) prescribing information, Amgen. Contraindication: Repatha ® is contraindicated in patients with a history of a serious hypersensitivity reaction to evolocumab or any of the excipients in Repatha ®.
Repatha belongs to a class of medications called PCSK9 inhibitors. These drugs help your body remove LDL (“bad”) cholesterol more effectively than it could on its own. They work differently than other drugs used for high cholesterol, such as statins, and have different side effects as well.
In the Fourier clinical trial within four weeks of being on Repatha the blood LDL cholesterol levels (median) have decreased 57% from baseline levels to 54mg/dl and with regular Repatha dosing these levels are consistently maintained to at least 50% below original baseline levels over 168 weeks.
It's a breakthrough medicine that reduces your risk of having a heart attack by 27%* and stroke by 21%†. Repatha® with a statin is proven to dramatically lower LDL bad cholesterol. Almost 90% of people lowered their LDL bad cholesterol to 70 mg/dL or below by taking Repatha® with a statin at 48 weeks.
Repatha is a human IgG2 monoclonal antibody produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology.
Action. FDA has approved Repatha (evolocumab) injection as an add-on treatment to diet alone or together with certain other therapies for patients aged 10 years and older with heterozygous familial hypercholesterolemia (HeFH) and homozygous familial hypercholesterolemia (HoFH).
Repatha is a medicine that is designed to be taken long term to reduce the risk of cardiovascular disease. Repatha works while you are using Repatha so if you stop taking Repatha, and once all of the Repatha has left your body, then it will stop having its beneficial effect.
Repatha has an average rating of 4.6 out of 10 from a total of 317 reviews for the treatment of High Cholesterol. 33% of reviewers reported a positive experience, while 56% reported a negative experience.
Repatha belongs to a class of medications called PCSK9 inhibitors. These drugs help your body remove LDL (“bad”) cholesterol more effectively than it could on its own. They work differently than other drugs used for high cholesterol, such as statins, and have different side effects as well.
The OLE studies showed Repatha delivered medically significant and sustained reduction in low-density lipoprotein cholesterol (LDL-C) levels, with 80% of patients achieving a low-density lipoprotein cholesterol (LDL-C) level of <55mg/dL.
Doctors prescribe Repatha to treat high cholesterol and lower the risk of cardiovascular problems. But, it can have adverse effects, such as upper respiratory symptoms, high blood pressure, and high glucose levels.
[Evolocumab (Repatha®) : a human monoclonal antibody against PCSK9 protein as potent cholesterol-lowering therapy]
Evolocumab injection is in a class of medications called proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor monoclonal antibody.
