These substances have been associated with adverse cardiovascular events, including acute myocardial infarction, hypertension, myocarditis, lethal cardiac arrhythmias, stroke, coronary thrombosis, and vasospasm. No reports on dilated cardiomyopathy secondary to use of Xenadrine EFX are published.

Phentermine is one of the most prescribed weight-loss medicines. But it isn't a good choice for people with heart disease, high blood pressure, an overactive thyroid gland or glaucoma. It also isn't for people who are pregnant, may become pregnant or are breastfeeding.

Ephedrine promotes sympathetic neuronal actions, causing the heart to beat more strongly and quickly [11]. It also increases metabolism and suppresses appetite, thus promoting body fat decomposition [12,13].

Cytodyne Technologies, Inc., which has discontinued its RFA line of Xenadrine, currently markets other products bearing the name Xenadrine that do not contain ma huang.

Xenadrine Clear has conjugated linoleic acid (CLA), medium chain triglyceride (MCT) oil, and BioPerine black pepper extract. It also contains a naturally sourced caffeine - coffea robusta or coffee extract. Xenadrine Pure contains apple cider vinegar, garcinia cambogia, and BioPerine.

One serving (2 capsules) of this product contains up to as much caffeine as 2 cups of coffee.

What you should know about weight-loss drugs. Mild side effects, such as nausea, constipation and diarrhea, are common. They may lessen over time. Rarely, serious side effects can happen.

Methods of weight loss that scientific research supports include the following:

1. Trying intermittent fasting.
2. Tracking your diet and exercise.
3. Eating mindfully.
4. Eating protein for breakfast.
5. Cutting back on sugar and refined carbohydrates.
6. Eating plenty of fiber.
7. Balancing gut bacteria.
8. Getting a good night's sleep.

The stimulating effects of caffeine and ephedrine are an additional contributing factor to weight loss. The stack's effect on the central nervous system results in increased aerobic exercise performance, measured as time until exhaustion relative to respiratory metrics.

Ephedrine is a direct and indirect sympathomimetic amine. As a direct effect, ephedrine activates alpha-adrenergic and beta-adrenergic receptors. As an indirect effect, it inhibits norepinephrine reuptake and increases the release of norepinephrine from vesicles in nerve cells.

Robusta coffee fruit extract (as Coffea robusta), Caffeine anhydrous (1,3,7-trimethylxanthine) , Yohimbe bark extract (as Pausinystalia yohimbe), Garcinia fruit extract (as Garcinia cambogia), L-Theanine, Spearmint leaf extract (as Mentha spicata), Autumn olive fruit extract (as Elaeagnus umbellata), Ashwagandha root ...

Xenadrine EFX is an ephedra-free weight loss product containing a mixture of caffeine, guarana, and bitter orange (standardized to synephrine). Synephrine has been shown in animals and humans to increase systemic vascular resistance and mean arterial pressure.

EPHEDRINE. Ephedrine is a natural product of the Ephedra plant; it is a commonly used noncatecholamine sympathomimetic (Table 34.6).

Using ephedrine alone or in combination with caffeine may cause: nausea. vomiting. anxiety.

From the metabolic point of view, combined ingestion of caffeine and ephedrine has been observed to increase blood glucose and lactate concentrations during exercise, wheareas qualitatively similar effects on lipid fuels (free fatty acids and glycerol) are less pronounced.

GLP-1 agonists are currently the most effective antiobesity medications and are considered safe for long-term use. Currently, only liraglutide (Saxenda) and semaglutide (Wegovy) are approved for weight loss, though some other GLP-1 drugs may be prescribed off-label.