The active ingredients in K9 Advantix, imidacloprid and permethrin, work by attacking the nervous system of fleas, ticks, and other parasites, but they are not known to have a sedative effect on dogs.

K9 Advantix II Dog Flea & Tick Drops is a topical prevention and tick, flea, and mosquito treatment for monthly use on dogs and puppies 7 weeks of age and older.

For over 20 years, dog owners have trusted the K9 Advantix® brand to kill and repel fleas, ticks and mosquitoes too. With one easy-to-apply topical treatment, K9 Advantix® II works all month to kill pests through contact so they don't have to bite your pet to die.

K9 Advantix II is a monthly preventative for dogs that offers comprehensive protection against ticks, fleas, mosquitoes, biting flies, and chewing lice.

PetCareRx says that K9 Advantix II is an effective flea treatment with a status of killing 98-100% of the fleas on dogs within 12 hours and continues to prevent infestations for at least four weeks. The medication also kills fleas before they lay eggs and kills flea larvae upon contact.

K9 Advantix® II Large Dog Topical Prevention and Treatment of Fleas, Ticks, Mosquitoes, Biting Flies, and Lice for Monthly Use Only on Dogs and Puppies 7 Weeks of Age and Older and Weighing 21 - 55 lbs.

K9 Advantix II offers added protection, working to kill and repel ticks and mosquitoes, and it repels biting flies.

Advantix II For Dogs kills 98-100% of the existing fleas on dogs within 12 hours. Re-infesting fleas are killed within 2 hours with protection against further flea infestation lasting at least four (4) weeks.

A single application of K9 Advantix® II remains effective for four weeks. However, if the dog has a severe infestation, retreatment within a month may be necessary. Do not retreat more than once every seven days.

Side Effects: Monitor your dog after application. Side effects, although very rare, may include signs of skin irritation such as redness, scratching, or other signs of discomfort. Gastrointestinal signs such as vomiting or diarrhea have also been reported.

Dogs treated with Advantix will be less likely to be bitten by mosquitoes or flies. Most veterinarians consider Advantix safe for dogs, but it is a strong medication that should be used with caution. The main active ingredients are imidacloprid and permethrin, both of which can be toxic in high doses.

Imidacloprid/permethrin/pyriproxyfen, sold under the trade name K9 Advantix II, is a combination insecticide product for dogs, used for the treatment and prevention of an array of common external parasites. It is effective against fleas, ticks, chewing lice and mosquitoes.