Assurance TV Spot, 'Attention: Over 65' Featuring Danny Glover.

Pseudobulbar affect, or PBA, is a neurological condition characterized by inappropriate, uncontrolled outbursts of laughing or crying. The ad did not mention any drug by name. But it was sponsored by Avanir Pharmaceuticals, the California firm that manufactures Nuedexta, a medicine that targets the disorder.

Overview. Pseudobulbar affect (PBA) is a condition that's characterized by episodes of sudden uncontrollable and inappropriate laughing or crying. Pseudobulbar affect typically occurs in people with certain neurological conditions or injuries, which might affect the way the brain controls emotion.

Danny Glover, (born July 22, 1947, San Francisco, California, U.S.), American actor, producer, and social activist who played a diverse range of characters but was perhaps best known for starring as a cautious veteran detective in the action blockbuster Lethal Weapon (1987) and its three sequels (1989, 1992, and 1998).

It was his Broadway debut in Fugard's Master Harold...and the Boys, which brought him to national recognition and led director Robert Benton to cast Glover in his first leading role in 1984's Oscar®-nominated Best Picture Places in the Heart.

Some people consider PBA a psychiatric disorder (mental illness) since the observable emotional changes (laughing or crying) are associated with mood. However, since PBA results from damaged neurological circuitry in your brain, PBA is best classified as a neuropsychiatric syndrome.

Pseudobulbar affect typically occurs secondary to a neurological injury or disease, such as:

• Alzheimer's disease.
• Amyotrophic lateral sclerosis (ALS)
• Brain tumors.
• Dementia.
• Multiple sclerosis.
• Stroke.
• Parkinson's disease.
• Traumatic brain injury (TBI)

High Emotional Situations and the Brain Some believe crying while laughing occurs because both reactions are a result of increased emotion. By crying, the body attempts to return to a regular level of functioning. Some evidence suggests the same part of the brain controls both crying and laughing.

Actor Danny Glover was born on July 22, 1946 in San Francisco, California. His parents, Carrie and James Glover, were both postal workers and active members of the NAACP. Glover was a student at Daniel Webster Elementary School and Roosevelt Middle School. He graduated from George Washington High School in 1964.

Donald Glover is a multi-talented writer, director, musician, and actor, known for his roles in "Community," "Atlanta," and more recently, The Lion King.

In 1987 Glover starred with Mel Gibson in Lethal Weapon, playing Roger Murtaugh. The film was a huge box-office hit and launched a successful franchise. During this time he continued to appear on the small screen, and in 1987 he portrayed South African leader Nelson Mandela in a television biography, Mandela (1987).

Pseudobulbar affect (PBA) is an affective disorder of emotional expression. It is associated with stroke, traumatic brain injury, brain tumor, Alzheimer's dementia, Parkinson's disease, multiple sclerosis, and motor neuron disorders like amyotrophic lateral sclerosis [1-3].