Heartgard Plus® is indicated for use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae for a month (30 days) after infection, and for the treatment and control of roundworms and hookworms.

While Heartgard Plus and Heartgard for dogs may sound similar, there is a fundamental difference between the two. While Heartgard offers protection against heartworm disease alone, Heartgard Plus tablets are effective against three types of worms, including heartworm, roundworm, and hookworm.

HEARTGARD® Plus (ivermectin/pyrantel) prevents heartworm disease and treats & controls 5 species of intestinal worms.*

The following adverse reactions have been reported following the use of HEARTGARD Plus chews: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions, and hypersalivation.

IMPORTANT SAFETY INFORMATION: HEARTGARD Plus is well tolerated. All dogs should be tested for heartworm infection before starting a preventive program. Following the use of HEARTGARD Plus, digestive and neurologic side effects have been reported. For more information, click here for full prescribing information.

This resulted in similar percentage efficacy of only 37.7% and 34.9% for Heartgard Plus and Interceptor Plus, respectively. The geometric mean worm count for the ProHeart 12-treated dogs was significantly lower (P < 0.0001) than those for the control group and for both Heartgard Plus and Interceptor Plus.

Heartworm treatment is expensive due to several factors: Heartworm medications are relatively new, and their high price is attributed to research and development costs. Moreover, the medication is often imported, making it more expensive to obtain.

IMPORTANT SAFETY INFORMATION: HEARTGARD Plus is well tolerated. All dogs should be tested for heartworm infection before starting a preventive program. Following the use of HEARTGARD Plus, digestive and neurologic side effects have been reported. For more information, click here for full prescribing information.

Heartgard Plus is a prescription pharmaceutical and requires veterinary authorization. This prescription medication will kill heartworms and control and treat hookworms. Every 30 days feed your dog one chewable tablet and your dog will be protected from heartworms and hookworms.

Efficacy. Heartgard is 95.6% effective in preventing heartworm disease in dogs [2]. One study found that two dogs treated with Heartgard Plus and tested positive for heartworms both lived in the Mississippi Delta [3].

For dogs 6 weeks of age and older with no minimum weight requirement. IMPORTANT SAFETY INFORMATION: HEARTGARD Plus is well tolerated. All dogs should be tested for heartworm infection before starting a preventive program. Following the use of HEARTGARD Plus, digestive and neurologic side effects have been reported.

This resulted in similar percentage efficacy of only 37.7% and 34.9% for Heartgard Plus and Interceptor Plus, respectively. The geometric mean worm count for the ProHeart 12-treated dogs was significantly lower (P < 0.0001) than those for the control group and for both Heartgard Plus and Interceptor Plus.