You might get injections in your forehead, temples, and the back of your head and neck. Sometimes the specialist will inject areas called “trigger points” where the headache pain originates.

BOTOX®(onabotulinumtoxinA) is a prescription medicine that is injected into muscles and used to prevent headaches in adults with chronic migraine who have 15 or more days each month with headache lasting 4 or more hours each day in people 18 years and older.

Results can last for 10 to 12 weeks, or sometimes longer. Most people receive Botox® treatments every three months for a year or more, until their migraine symptoms ease. For some people, migraines may go away completely over time.

Bottom Line. The recommended total dose of Botox (onabotulinumtoxinA) for chronic migraine prevention is 155 Units administered intramuscularly (into the muscle). This is given as 0.1 mL (5 Units) injections divided across 7 specific head and neck muscle areas, for a total of 31 individual injections per session.

Injection Administration Sites

• Corrugator and Proserus. Injection is started in the glabellar region.
• Frontalis. There are a total of four injection sites in the frontalis muscle.
• Temporalis. A total of 8 injections are administered into bilateral temporal muscles.
• Occipitalis.
• Paraspinal Muscle Group.
• Trapezius.

The Best Places for Botox on Face

• Frown Lines (vertical lines between the brows)
• Bunny Lines (horizontal lines on the nose)
• Forehead Wrinkles.
• Crow's Feet (lines at the outer corners of the eyes)
• Eyebrows (brow lift)
• Lip lines or Upper lip (lipstick lines or gummy smile)

The mechanism by which Botox works to treat migraine is complex. It is thought to function by reducing the release of inflammatory and excitatory neurotransmitters and proteins.

The only difference between the two procedures is that with Botox for migraines, they may do a few more shots in areas where the pain is experienced.

A good response to Botox is usually a 30-50% reduction in how many headaches you have. Doctors will also consider any improvements in your quality of life.

It is not a cure. People who receive Botox for headaches usually get the treatment about every three months. For some, that is all they need to keep their headaches under control. For others, additional medication or other headache treatment is necessary.

Number of units – The basic recommendation from the manufacturer of Botox Cosmetic is four units for each of the injection sites (20 total).

The recommended dilution is 200 Units/4 mL or 100 Units/2 mL, with a final concentration of 5 Units per 0.1 mL (see Table 1). The recommended dose for treating chronic migraine is 155 Units administered intramuscularly using a sterile 30-gauge, 0.5 inch needle as 0.1 mL (5 Units) injections per each site.