Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. At the same time, Simparica Trio is used to prevent heartworm and lungworm disease (both caused by blood worms that infect the heart and blood vessels supplying the lungs).

For flea or tick infestations, one treatment with Simparica Trio is effective for up to 5 weeks. Further flea or tick treatment should be continued using a different veterinary medicine with a narrower range of action. To prevent lungworm and heartworm disease for one month, a single treatment is required.

Simparica Trio has not demonstrated efficacy against whipworms or tapeworms in dogs or puppies. However, if you are dispensing Simparica Trio to a dog or puppy and such dog or puppy is found to be positive with tapeworms demonstrated in the fecal sample, we will provide you Cestex (epsiprantel) free of charge.

Simparica Trio is the first and only product that combines sarolaner, moxidectin, and pyrantel in one simple-to-give chewable - for protection against:

• Heartworm disease.
• Ticks* & fleas.
• Roundworms & hookworms. †
• Infections that may cause Lyme disease by killing deer ticks.

Simparica flea and tick medicine are proven to be 96.9 percent effective at killing fleas and ticks in dogs, and it starts working in three to eight hours after the first tablet. If your dog has a flea infestation, the medication will kill the existing fleas and prevent new infestations on your pet.

IMPORTANT SAFETY INFORMATION Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders.

Oral preventatives containing isoxazoline (e.g. Nexgard, Simparica, Credelio, Bravecto) also do not prevent tick attachment, but they have a relatively fast tick kill time.

For those of us that don't always remember to give our preventatives on day 30, Simparica's effects will last until day 35 without tapering off, providing continuous protection. This allows owners a 5 day margin of error should they forget to give their preventatives on time.

Simparica kills adult fleas so fast they don't get a chance to lay eggs and reproduce. Why can I still see fleas on my dog after giving Simparica? Fleas can live in a variety of areas outside of your home as well as on other dogs that your dog may encounter.

Simparica kills adult fleas, and is indicated for the treatment and prevention of flea infestations (Ctenocephalides felis), and the treatment and control of tick infestations [Amblyomma americanum (lone star tick), Amblyomma maculatum (Gulf Coast tick), Dermacentor variabilis (American dog tick), Ixodes scapularis ( ...

Simparica Flea and Tick Medicine If your dog has a flea infestation, the medication will kill the existing fleas and prevent new infestations on your pet.

The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).