Herbalists and clinicians alike used the milk thistle for hundreds of years to treat a wide range of liver pathology, including fatty liver disease, hepatitis, cirrhosis, and to protect the liver from environmental toxins. Today, millions of people consume milk thistle to support healthy liver function.

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Milk thistle will help to detoxify chemicals and toxins that accumulate in the body, accelerate the regeneration of liver cells, and improve liver function over time. It certainly isn't a fad, yet the true extent of its benefits is still to be uncovered.

While some common ingredients in liver cleanses have been shown to have positive results - milk thistle has been shown to decrease liver inflammation, and turmeric extract has been shown to protect against liver injury - there have not been adequate clinical trial data in humans to recommend the routine use of these ...

Researchers say milk thistle is well tolerated by most people. And they suggest taking up to 700 mg of milk thistle three times per day for 24 weeks has been shown to be safe.

The evidence for milk thistle's liver cleansing properties comes mainly from traditional medicine. If you would like to try a liver cleanse with milk thistle, we recommend taking it every day for at least two weeks.

Many liver detoxification products are also sold as weight loss cleanses. However, there are no clinical data to support the efficacy of these cleanses. In fact, some dietary supplements can actually cause harm to the liver by leading to drug-induced injury and should thus be used with caution.

Can liver detox cause any temporary side effects? It is possible to experience mild detoxification symptoms such as headaches, fatigue, or changes in bowel movements. These usually subside as the body adjusts.

Milk thistle is considered safe in dosages of 420 mg/day orally in divided doses for up to 41 months.

Adverse effects associated with oral ingestion of milk thistle include:

• Gastrointestinal problems (e.g., nausea, diarrhea, dyspepsia, flatulence, abdominal bloating, abdominal fullness or pain, anorexia, and changes in bowel habits).
• Headache.
• Skin reactions (pruritus, rash, urticaria, and eczema).

Myth #1: Liver cleanses are important for daily health maintenance and are especially helpful after you've overindulged. Though liver cleanses are packaged to claim that they're a cure-all for daily liver health and overindulgence, Johns Hopkins hepatologists do not recommend them.

The bottom line. Since your liver cleans itself, there's no need to do any kind of liver cleanse or detox - and in fact, those things could cause more harm than good. Instead, focus on keeping your liver healthy by exercising regularly, eating a balanced diet and limiting your alcohol intake.

Researchers say milk thistle is well tolerated by most people. And they suggest taking up to 700 mg of milk thistle three times per day for 24 weeks has been shown to be safe.

Milk thistle can be taken any time of day, but it is recommended to take it with meals. Your body is able to absorb the active compounds in milk thistle more effectively if you have recently eaten. Plus, taking milk thistle after a heavy meal can help improve digestion and relieve digestive discomfort.

Milk thistle is generally considered safe when taken by mouth ( 1 , 45 ). In fact, in studies where high doses were used for long periods, only about 1% of people experienced side effects ( 1 ). When reported, side effects for milk thistle are generally gut disturbances like diarrhea, nausea or bloating.

Early research shows that taking milk thistle extract together with conventional treatment might help treat kidney disease in people with diabetes.