After 20 years of dealing with very painful menstrual cramps, this product is the best thing that's worked to alleviate them (along with other PMS symptoms). It usually takes 45-60 minutes to kick in.

This product is a combination of aspirin, acetaminophen, and caffeine. It is used for the temporary relief of pain from conditions such as muscle aches, toothaches, menstrual cramps, or headaches (including migraine). Aspirin and acetaminophen relieve pain by keeping your body from making certain natural substances.

The typical Pamprin dosage is 2 caplets by mouth every 6 hours as needed. You shouldn't take more than 8 caplets in 24 hours. Pamprin Multi Symptom (acetaminophen/pamabrom/pyrilamine) can be used by adults and adolescents ages 12 years and older.

Take 2 capsules when your period symptoms start, typically 2-3 days before your period and take for the duration of your period.

Pamprin Multi-Symptom Maximum Strength can make you sleepy or dizzy during the day, which can affect your ability to focus, think, or react. Don't drive until you know how the medication affects you.

Upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Pamprin Multi-Symptom Maximum Strength can make you sleepy or dizzy during the day, which can affect your ability to focus, think, or react. Don't drive until you know how the medication affects you.

See also Warning section. Upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

What is the most important information I should know about Pamprin Cramp Formula (Apap Magnesium Salicylate Pamabrom)? You should not take this medication if you are allergic to acetaminophen (Tylenol), magnesium salicylate (Nuprin), pamabrom, aspirin or other NSAIDs.

Pamprin Multi-Symptom Maximum Strength can make you sleepy or dizzy during the day, which can affect your ability to focus, think, or react. Don't drive until you know how the medication affects you.

Pamprin Multi-Symptom Maximum Strength is generally safe to take, but it's not the best choice for everyone. If you're 65 years or older or taking other medications that make you sleepy, the pyrilamine in this medication can raise your risk for falls and trouble urinating.

Adults and children 12 years and over: take 2 caplets with water every 6 hours as needed. Do not exceed 8 caplets in a 24 hour period or as directed by a doctor. Do not use more than directed (see warnings).