After 20 years of dealing with very painful menstrual cramps, this product is the best thing that's worked to alleviate them (along with other PMS symptoms). It usually takes 45-60 minutes to kick in.

What is the most important information I should know about Pamprin Cramp Formula (Apap Magnesium Salicylate Pamabrom)? You should not take this medication if you are allergic to acetaminophen (Tylenol), magnesium salicylate (Nuprin), pamabrom, aspirin or other NSAIDs.

Acetaminophen/pamabrom/pyrilamine is an over-the-counter (OTC) product used for pain relief from menstrual cramps. Acetaminophen/pamabrom/pyrilamine is available under the following different brand names: Midol Maximum Strength PMS, Pamprin Multi-Symptom Maximum Strength, and Premsyn PMS.

Pamabrom is a water pill that tells your kidneys to make more urine. This helps remove the extra fluid in your body. Pyrilamine is an antihistamine that blocks a natural substance in your body called histamine. By blocking histamine, pyrilamine lowers inflammation (redness, swelling, pain).

Periods go beyond pain. That's why Pamprin goes beyond simply relieving pain like ordinary pain relievers do. We have the same pain reliever as Extra Strength Tylenol to relieve cramps, headache, and backache, PLUS powerful ingredients to ease bloating and irritability too.

Common side effects of Pamprin Multi-Symptom may include:

• dizziness, drowsiness;
• dry mouth, nose, or throat;
• constipation;
• blurred vision; or.
• feeling restless or excited (especially in children).

A: Pamprin Multi-Symptom, the only period product that relieves pain, irritability & bloating, contains pyrilamine maleate, an antihistamine for irritability. It also contains pamabrom, a diuretic for bloating, & acetaminophen, a pain reliever.

Pamprin Multi-Symptom Maximum Strength can make you sleepy or dizzy during the day, which can affect your ability to focus, think, or react. Don't drive until you know how the medication affects you.

Upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Pamprin Multi-Symptom Maximum Strength is a combination of three medications: acetaminophen (an analgesic), pamabrom (a diuretic, or water pill), and pyrilamine (an antihistamine).

See also Warning section. Upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.