Non-24-hour sleep-wake disorder (N24) is a circadian rhythm sleep disorder in which an individual's biological clock fails to synchronize to a 24-hour day. Instead of sleeping at roughly the same time every day, someone with N24 will typically find their sleep time gradually delaying by minutes to hours every day.

Hetlioz (tasimelteon) is also used to treat sleep disturbances in patients with Smith-Magenis Syndrome (SMS). It's the first and currently only FDA-approved treatment for people with non-24 and SMS. Since it's only available as a brand name, it can be expensive.

Non-24 is a circadian rhythm disorder and occurs because our internal clock is not synched with light and dark cycles of the day and night. Most individuals with this disorder are totally blind. That's because your internal clock gets its cue from seeing light. But sometimes people who have normal vision also get it.

Nobody knows how many people have N24, but it is very rare. It took a team of researchers [1] 10 years to find 57 cases. N24 was first discovered in 1971 and is “extremely debilitating in that it is incompatible with most social and professional obligations” [3].

HETLIOZ® (tasimelteon) is the first and only medication proven to treat Non-24. There's an FDA-approved therapy that may help you sleep at night and stay awake during the day. Ask your doctor about the first and only treatment for people who are totally blind with Non-24, called HETLIOZ® (tasimelteon).

Welcome to HETLIOZ® (tasimelteon) The first and only FDA-approved treatment for Non-24-Hour Sleep-Wake Disorder (Non-24).

Treatment for non-24-hour sleep-wake disorder (N24SWD) aims to establish a 24-hour sleep-wake cycle, or “entrain (synchronize) the circadian rhythm.” This process commonly involves using melatonin, bright light therapy, or other methods that are known to influence the circadian rhythm.

HETLIOZ® (tasimelteon) is the first and only medication proven to treat Non-24. There's an FDA-approved therapy that may help you sleep at night and stay awake during the day. Ask your doctor about the first and only treatment for people who are totally blind with Non-24, called HETLIOZ® (tasimelteon).

There's no cure, but treatments, including hormones, medicine, and light therapy, can help get you closer to a normal sleeping pattern.

Although this sleep disorder is more common in blind people, affecting up to 70% of the totally blind, it can also affect sighted people. Non-24 may also be comorbid with bipolar disorder, depression, and traumatic brain injury.

Some drugs say "24 hour" or "12 hour." You can buy both versions of Sudafed, for example, and each comes with a "long-acting" claim. All it means is that their active ingredients are released during a certain amount of time. Our advice: Read instructions, even for products that claim to last a certain number of hours.

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