MOVANTIK blocks opioids from attaching to something called “mu-receptors” in your bowels - directly targeting the area impacted by opioid-induced constipation. This design helps provide relief efficiently and enable bowel movements.

If Movantik (naloxegol) doesn't work well enough, you can continue to take laxatives like Dulcolax (bisacodyl) or enemas to help with your constipation. Is Movantik (naloxegol) a stool softener?

Pain medications, called “opioids” (such as morphine, hydromorphone, oxycodone and Tylenol #3,) may cause constipation. Opioids slow down the movement of stool through your bowel (intestines). This gives your bowel more time to take the water out of your stool, making it hard, dry and difficult to pass.

MOVANTIK may cause serious side effects, including: Opioid withdrawal. You may have symptoms of opioid withdrawal during treatment with MOVANTIK, including sweating, chills, diarrhea, stomach pain, anxiety, irritability, and yawning.

MOVANTIK is a prescription medicine used to treat constipation that is caused by prescription pain medicines called opioids, in adults with long-lasting (chronic) pain that is not caused by active cancer. Click here for the Medication Guide and full Prescribing Information for MOVANTIK.

The recommended MOVANTIK dosage is 25 mg once daily in the morning. If patients are not able to tolerate MOVANTIK, reduce the dosage to 12.5 mg once daily [see Clinical Pharmacology (12.2)].

MOVANTIK is taken once a day in the morning, on an empty stomach,* for the duration of opioid treatment. In the same 2 studies, response rate for MOVANTIK was 40% to 44% with a 25 mg dose and 35% to 41% with a 12.5 mg dose.

Try a Different Opioid Some studies have found that fentanyl may cause less constipation than morphine. Tapentadol may also be easier on your intestines than oxycodone. Methadone may also be less constipating. Talk to your doctor about which drugs will give you the right balance of pain relief and fewer side effects.

Stimulants. It's better to try these if your constipation is severe and other drugs haven't worked. They cause your intestines to squeeze so things get moving. Two of the more common ones are bisacodyl (Correctol, Ducodyl, Dulcolax) and sennocides (Senexon, Senokot).

In 2 clinical studies, MOVANTIK worked quickly - often within 6 to 12 hours of the first dose. MOVANTIK is taken once a day in the morning, on an empty stomach,* for the duration of opioid treatment. In the same 2 studies, response rate for MOVANTIK was 40% to 44% with a 25 mg dose and 35% to 41% with a 12.5 mg dose.

The average cost for 30 Tablet(s), 25mg each, is $478.99. You can buy Movantik at the discounted price of $404.23 by using the WebMDRx coupon, a savings of 16%. Even if this drug is covered by Medicare or your insurance, we recommend you compare prices. The WebMDRx coupon or cash price may be less than your co-pay.

MOVANTIK should be taken exactly as your health care provider tells you. *At least 1 hour before the first meal of the day or 2 hours after the meal. Consumption of grapefruit or grapefruit juice during treatment with MOVANTIK is to be avoided.