Excedrin® Migraine contains three components: acetaminophen, aspirin, and caffeine, which help target pain in different ways. Research has demonstrated that not only is this combination of ingredients effective in treating migraines, but it is also significantly more effective than the individual components alone.

Excedrin Migraine is a popular over-the-counter (OTC) medication for treating occasional migraine headaches. Excedrin Migraine contains a combination of acetaminophen, aspirin, and caffeine. This combination has been shown to work better for migraines than other OTC single ingredient medications.

Acetaminophen, one of the drugs in Excedrin Migraine, can cause severe liver damage. You have a higher risk of liver damage if you take Excedrin Migraine and do any of the following: use more than the maximum daily amount (two caplets in 24 hours) take other products that contain acetaminophen.

Advil Migraine and Excedrin Migraine are both effective for treating migraines. Research shows that the ingredients in Excedrin Migraine are more effective at reducing migraine pain than ibuprofen. The ingredients in Excedrin Migraine also kick in about 20 minutes faster.

The antihistamine in this product may cause drowsiness, so it can also be used as a nighttime sleep aid. Antihistamines can also be used to help relieve allergy or cold symptoms such as watery eyes, itchy eyes/nose/throat, runny nose, and sneezing.

Triptans. Prescription drugs such as sumatriptan (Imitrex, Tosymra) and rizatriptan (Maxalt, Maxalt-MLT) are used to treat migraine because they block pain pathways in the brain. Taken as pills, shots or nasal sprays, they can relieve many symptoms of migraine.

A: Two Excedrin a day could be too much. In the long run, it can lead to more headaches from what we call "rebound headache." This can happen with any pain-relieving medication, but happens to be particularly more common with compounds like Excedrin. We recommend limiting pain medications to three days a week or less.

Prescription drugs such as sumatriptan (Imitrex, Tosymra) and rizatriptan (Maxalt, Maxalt-MLT) are used to treat migraine because they block pain pathways in the brain. Taken as pills, shots or nasal sprays, they can relieve many symptoms of migraine.

Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as confusion), trouble urinating. A very serious allergic reaction to this drug is rare.

Excedrin Migraine can relieve symptoms in 30 minutes³. Most people experience significant relief and alleviation of migraine symptoms in the first few hours. You may be pain-free within a few hours of taking Excedrin Migraine. Pain relief usually lasts up to six hours.

Whether it's a run-of-the-mill tension headache or a migraine, caffeine can help. That's why it's an ingredient in a lot of popular pain relievers. It can make them as much as 40% more effective. Sometimes you can stop the pain in its tracks just by having caffeine alone.

A migraine usually lasts from 4 to 72 hours if untreated. How often migraines occur varies from person to person. Migraines might occur rarely or strike several times a month.