Nature Made Melatonin Extended Release uses a specially formulated dual action tablet to release Melatonin both immediately and gradually throughout the night to help you fall asleep faster and stay asleep longer.

“ZzzQuil PURE Zzzs All-Night tablets uses extended release melatonin to get you to sleep and help you stay asleep. Using melatonin, valerian root and lavender as ingredients that you take 30 minutes before you go to bed, it allows you to feel drowsy so you can fall asleep.”

TIME RELEASE FORMULA – Natrol Melatonin Time Release tablets provide an initial dosage of melatonin to help you fall asleep fast, then slowly releases additional melatonin throughout the night to help you stay asleep so you can wake up refreshed.

They dissolve as soon as you take them, which instantly releases melatonin into your bloodstream. On the other hand, extended release melatonin dissolves slowly. It gradually releases melatonin over time, which may mimic the way your body naturally makes melatonin throughout the night.

around one to two hours How long does Melatonin take to work? Natural Melatonin production in the body begins to increase around one to two hours before your regular bedtime. Everyone reacts differently, but when taking Melatonin to support your sleep, it's best to take the recommended Melatonin dosage one hour before your bedtime [1].

Extended-release melatonin had a longer time to peak concentration (1.56 vs 0.6 h) and elimination half-life (1.63 vs 0.95 h) compared with immediate-release melatonin. Maximum concentration was lower for extended-release melatonin compared with immediate-release melatonin (7581 pg/mL vs 13120 pg/mL).

Typical melatonin doses are between 1 and 5 milligrams, although some products go to as high as 20 mg.

Our Picks for the Best Melatonin Supplements in 2023:

• Best Melatonin Overall: KOS Sleep Gummies.
• Best Sustained Release Melatonin: Kaged Sleep SR.
• Best Melatonin for Sleep: Transparent Labs Sleep Aid.
• Best Melatonin Capsule: Kaged Sleep SR.
• Best Melatonin Gummies: Olly Extra Strength Sleep.

Taking more than 10mg of melatonin is not recommended by healthcare professionals, and could lead to melatonin overdose, which comes with a host of potential negative side effects. These more serious side effects may include: Excessive sleepiness.

Generally, a safe starting dose for adults is between 1 and 5 milligrams of melatonin. Older adults may find doses lower than 1 milligram to be effective. Children should not take melatonin unless recommended by a doctor.

There is no official recommended maximum dose of melatonin for adults, but a range of 0.5 mg to 5 mg appears to be safe and effective. Generally speaking, most people produce enough melatonin to sleep well, but if you need a little extra to add to their sleep cycle, you probably don't need more than 3 mg.

It's important to note that there isn't a “safe” dosage of melatonin. Generally, an adult dose is thought to be between 1 and 10 mg. Doses near the 30 mg mark are usually considered to be harmful. However, people's sensitivity to it can vary, making some more prone to side effects at lower doses than others.