The results showed that in people who used high-dose acetaminophen, systolic blood pressure (the top number) increased about five points more than those who took a placebo. This doesn't mean people with hypertension should never take acetaminophen for aches and pains.

I'm not advocating taking one version over the other – you'll have to spend some time thinking about which version is the right one for you, but the answer to the frequently asked question above is that “Tylenol Arthritis” contains slightly more acetaminophen than Extra Strength Tylenol. It contains no other drugs.

Extra-strength Tylenol is 500 mg but still only lasts 3-4 hours. Tylenol Arthritis is 650 mg, but the key is that it is a sustained-release formulation that lasts about 8 to 12 hours.

• Active ingredient. Acetaminophen 650 mg (in each caplet)
• Purpose.
• Inactive ingredients. carnauba wax, hydroxyethyl cellulose, hypromellose, magnesium stearate, microcrystalline cellulose, modified starch, povidone, powdered cellulose, pregelatinized starch, sodium starch glycolate, titanium dioxide, triacetin.

What Is New? Regular acetaminophen use increases both systolic and diastolic blood pressure in individuals with hypertension, with an effect similar to that of nonsteroidal anti-inflammatories. This rise in blood pressure is seen both in those taking and not taking antihypertensive therapy.

Is Tylenol safe to use? Tylenol (acetaminophen) is one of the safest pain medications to use if you've had a heart attack. While it may be less effective than NSAIDs, many people still find that it helps with pain relief. Tylenol doesn't have the same risks as NSAIDs when it comes to your heart.

Key takeaways: For people with high blood pressure, Tylenol (acetaminophen) has been considered the safest over-the-counter pain medication. It's still a safe choice, but emerging evidence shows it may affect blood pressure.

Acetaminophen appears safe for both your heart and gut. "But unlike NSAIDs, acetaminophen has no effect on inflammation, which is at the root of the arthritic conditions that plague many people," says Dr. Antman. Also, be aware that high doses of acetaminophen can damage your liver.

What is acetaminophen used for? Acetaminophen is most commonly used to treat minor aches and pains, including headache, backache, minor pain of arthritis, toothache, muscular aches, premenstrual and menstrual cramps. It is also commonly used to temporarily reduce fever.

Taking too much acetaminophen may cause serious (possibly fatal) liver disease. Adults should not take more than 4000 milligrams (4 grams) of. People with liver problems and children should take less acetaminophen. Ask your doctor or pharmacist how much acetaminophen is safe to take.

What Is New? Regular acetaminophen use increases both systolic and diastolic blood pressure in individuals with hypertension, with an effect similar to that of nonsteroidal anti-inflammatories. This rise in blood pressure is seen both in those taking and not taking antihypertensive therapy.

Some common types of OTC medicines you may need to avoid include:

• Decongestants, such as those that contain pseudoephedrine.
• Pain medicines (NSAIDs), such as ibuprofen and naproxen.
• Cold and flu medicines.
• Some antacids and other stomach medicines.
• Some herbal remedies and dietary supplements.