This doesn't mean people with hypertension should never take acetaminophen for aches and pains. Yet, it's best to use the lowest effective dose, and no more than two regular-strength (325-mg) tablets every six hours, or two extra-strength (500-mg) tablets every eight hours.

Experts believe that acetaminophen is safe for people with high blood pressure. Acetaminophen is also less likely to cause gastrointestinal problems than NSAIDs. It is safe for women who are pregnant and nursing. Side effects and risks.

What Is New? Regular acetaminophen use increases both systolic and diastolic blood pressure in individuals with hypertension, with an effect similar to that of nonsteroidal anti-inflammatories. This rise in blood pressure is seen both in those taking and not taking antihypertensive therapy.

Amlodipine and celecoxib combination is used to treat high blood pressure (hypertension) and help relieve the symptoms of osteoarthritis (eg, swelling, stiffness, and joint pain). Amlodipine is a calcium channel blocker (CCB). It affects the movement of calcium into the cells of the heart and blood vessels.

Acetaminophen appears safe for both your heart and gut. "But unlike NSAIDs, acetaminophen has no effect on inflammation, which is at the root of the arthritic conditions that plague many people," says Dr. Antman. Also, be aware that high doses of acetaminophen can damage your liver.

Which medications are safe for high blood pressure?

• ACE inhibitors (benazepril, zofenopril, lisinopril, and others)
• angiotensin II receptor blockers (losartan and valsartan)
• beta-blockers (acebutolol, atenolol, bisoprolol, and others)
• calcium channel blockers (amlodipine and diltiazem)

Some common types of OTC medicines you may need to avoid include:

• Decongestants, such as those that contain pseudoephedrine.
• Pain medicines (NSAIDs), such as ibuprofen and naproxen.
• Cold and flu medicines.
• Some antacids and other stomach medicines.
• Some herbal remedies and dietary supplements.

Some early studies show that acetaminophen may protect the heart. Though the jury is still out, there have been studies that show acetaminophen may help the heart when taken as directed. In animals, it has been shown to slow the heartbeat and make it more regular and strong.

NSAIDs are the most effective oral medicines for OA. They include ibuprofen (Motrin, Advil) naproxen (Aleve) and diclofenac (Voltaren, others). All work by blocking enzymes that cause pain and swelling. The problem is that some of those enzymes also help blood to clot and protect the lining of your stomach.

People who suffer from hypertension often complain of experiencing a dull ache all over their body, particularly in the joints and muscles. This is because your weakened blood vessels cannot pump enough blood and oxygen to the muscles of your body, which causes a dull ache.

Some pain medications are safer to take than others. Acetaminophen (Tylenol) and topical pain relievers are the preferred pain relievers to take if you have heart failure. Pain medications like gabapentinoids, opioids, and long-term NSAIDs should be avoided if you have heart failure.

Nitroglycerin - usually taken as a tablet under the tongue - relaxes heart arteries so blood can flow more easily through the narrowed spaces. Some blood pressure medicines also relax and widen blood vessels. Aspirin.