Excedrin® Migraine contains three components: acetaminophen, aspirin, and caffeine, which help target pain in different ways. Research has demonstrated that not only is this combination of ingredients effective in treating migraines, but it is also significantly more effective than the individual components alone.

Why is there a shortage of Excedrin®? In their official statement, GlaxoSmithKline said they've halted production because of “inconsistencies in how we transfer and weigh ingredients.” There isn't a nationwide shortage yet, but drugstores won't be able to restock once they run out of their current supply.

The dosage limit on Excedrin Migraine is to help prevent rebound headaches. These can happen if you take pain relievers too often or take more than recommended. Often, rebound headaches can create a vicious cycle. These headaches appear when the medicine wears off - which then prompts you to take more medicine.

Advil Migraine and Excedrin Migraine are both effective for treating migraines. Research shows that the ingredients in Excedrin Migraine are more effective at reducing migraine pain than ibuprofen. The ingredients in Excedrin Migraine also kick in about 20 minutes faster.

A: Two Excedrin a day could be too much. In the long run, it can lead to more headaches from what we call "rebound headache." This can happen with any pain-relieving medication, but happens to be particularly more common with compounds like Excedrin. We recommend limiting pain medications to three days a week or less.

The antihistamine in this product may cause drowsiness, so it can also be used as a nighttime sleep aid. Antihistamines can also be used to help relieve allergy or cold symptoms such as watery eyes, itchy eyes/nose/throat, runny nose, and sneezing.

Stop taking this medication and tell your doctor right away if you have any serious side effects, including: stomach/abdominal pain that is severe or doesn't go away, severe dizziness, fainting, vomit that looks like coffee grounds, black/bloody stools, ringing in the ears, loss of hearing, irregular/fast heartbeat, ...

Is Excedrin being discontinued? No, Excedrin products have not been discontinued.

Official answer. The usual adult dose for Excedrin Migraine is 2 caplets with a glass of water. Do not take more than 2 caplets in a 24 hour period, unless directed by your doctor. Excedrin Migraine contains 250 mg of acetaminophen, 250 mg of aspirin (an NSAID), and 65 mg of caffeine per caplet or geltab.

Triptans. Prescription drugs such as sumatriptan (Imitrex, Tosymra) and rizatriptan (Maxalt, Maxalt-MLT) are used to treat migraine because they block pain pathways in the brain. Taken as pills, shots or nasal sprays, they can relieve many symptoms of migraine.

A: Two Excedrin a day could be too much. In the long run, it can lead to more headaches from what we call "rebound headache." This can happen with any pain-relieving medication, but happens to be particularly more common with compounds like Excedrin. We recommend limiting pain medications to three days a week or less.

But if you suffer from nighttime headaches, “head pain” is one of the reasons to add to the list - so you may consider taking a sleep aid and pain reliever to help you fall asleep. Excedrin® PM Headache is a non-habit-forming nighttime sleep aid that has provided safe and effective relief for over 40 years.