Simparica Trio is a parasite preventative used to protect your pet from fleas, ticks, and other parasites. While it's generally well-tolerated by dogs, pet parents should discuss the potential side effects and Simparica Trio alternatives with their vet beforehand.

The cumulative deaths reported to April 2021 ranged from a high of 2,627 (24%) for fluralaner (Bravecto®) to 726 (2.8%) for afoxolaner (NexGard®) and 412 (12.7%) for sarolaner (Simparica®).

Simparica Trio is considered safe for dogs as young as eight weeks old who weigh at least 2.8 pounds. However, the product has not been evaluated in breeding, pregnant, or lactating dogs.

Simparica is a once-monthly, safe, and effective chewable flea and tick preventative for use in dogs. Available with a prescription only, this product works rapidly and offers a full month of protection. It begins killing fleas within 3 hours and ticks within 8, and it maintains efficacy until the next monthly dose.

Here's what you should know. The FDA recently released an alert that reads: “The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats.” but went on to warn pet owners and veterinarians about potential neurological reactions to the isoxazoline class of drugs.

Since these products have obtained their respective FDA approvals, data received by the agency as part of its routine post-marketing activities indicates that some animals receiving Bravecto, Nexgard or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.

Shows. The number of dog owners who think otherwise. Is growing try to resuscitate him. And he was pronounced dead on arrival. Life hasn't been the same without him I mean.

Simparica may cause neurologic signs such as tremors, unsteadiness and/or seizures in dogs with or without a history of neurologic disorders. Simparica has not been evaluated in pregnant, breeding or lactating dogs. The most common adverse reactions in clinical trials were vomiting and diarrhea.

Simparica kills both fleas and ticks, while Frontline Plus is effective against fleas, ticks, flea eggs and larvae and lice. Simparica kills fleas within 3 hours and kills ticks within 8 hours. Frontline Plus kills fleas within 12 hours and ticks within 48.

Both products are safe for dogs when following directions and have been approved by the FDA to treat and prevent flea and tick infestations. While Simparica was trialed and not approved, Nexgard has not yet been evaluated for use in breeding, pregnant, or lactating dogs.

If you have a breeding dog, a pregnant dog, or a puppy between 6 and 8 weeks old, Heartgard Plus is the safest option. If you're hoping to find a broad-spectrum product that protects against fleas and ticks while it defends against internal parasites, Simparica Trio is the clear winner.

Seizures were at the top of the list, with documents showing 1,315 seizures from Nexgard in the five years since the FDA approved it as safe and effective for most dogs. That same information showed 720 reported seizures for Bravecto in four years and 557 for Simparica in three years.