Denosumab injection (Prolia) is used treat osteoporosis that is caused by corticosteroid medications in men and women who will be taking corticosteroid medications for at least 6 months and have an increased risk for fractures or who cannot take or did not respond to other medication treatments for osteoporosis.

Specifically, Prolia works by blocking a protein called RANK. The drug attaches to the RANK protein and helps prevent osteoclasts from breaking down bone. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. This lowers your risk for bone fractures.

• The active substance is denosumab. Each 1 mL pre-filled syringe contains 60 mg of denosumab (60 mg/mL).
• The other ingredients are acetic acid, glacial, sodium hydroxide, sorbitol (E420), polysorbate 20 and water for injections.

Prolia reduced the risk of vertebral fractures by 4.8%, hip fractures by 0.3%, and nonvertebral fractures by 1.5%. Bone mineral density was increased by 8.8% in the spine, 6.4% in the hip, and 5.2% in the neck after three years of treatment with Prolia.

How long can I stay on Prolia for? For Prolia to work well at reducing fractures it needs to be taken long term and in one phase 2 clinical trial it has been used safely for up to 8 years with substantial increase in bone density, although most clinical trials are for 3 or 4 years.

Continue using Prolia for as long as your doctor tells you to. Prolia can treat osteoporosis and bone loss only for as long as you keep having treatment. Please talk to your doctor before you consider stopping treatment. You should also take calcium and vitamin D supplements while receiving Prolia.

Prolia® injection is a brand of denosumab, which treats osteoporosis. Osteoporosis is a condition that weakens your bones, making them more susceptible to fractures. Xgeva® is another brand of denosumab that treats high calcium levels caused by cancer and prevents bone breaks.

Denosumab (brand name Prolia) is a medication used to treat severe osteoporosis. It works by turning off the natural process of breaking down and reabsorbing bones. It is administered through a shot twice per year for up to 10 years.

Prolia is an injection used to treat osteoporosis. It is given by your healthcare provider as a shot under the skin every 6 months. It's recommended as a first-choice medication for certain people with osteoporosis. Though, it can cause side effects such as muscle pain, back pain, and jaw osteonecrosis.

Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. Musculoskeletal pain refers to pain in your bones, muscles, tendons, and ligaments. Bone pain from Prolia may be most noticeable in your arms and legs.

Stopping Prolia Abruptly Raises Fracture Risk Bisphosphonates have an effect in the skeleton even after people stop taking them and can impact bone reabsorption for years after treatment discontinuation, says Dr.

In this study, the females' bone mineral density (BMD) was measured. (BMD is a measurement that shows how strong your bones are.) After 12 months of treatment, BMD measured at the hip was increased by 3.5% in females taking Prolia.

Answer. Denosumab (brand name Prolia) is a medication used to treat severe osteoporosis. It works by turning off the natural process of breaking down and reabsorbing bones. It is administered through a shot twice per year for up to 10 years.

Official answer. Yes, Prolia (denosumab) does increase bone density.

Fosamax is usually the first-choice option for osteoporosis. But Prolia may be preferred in people with very high fracture risk. The most common side effects of Boniva and Fosamax are gastrointestinal symptoms like acid reflux, nausea, and diarrhea.

Researchers and physicians recommend that you do not stop taking Prolia without making a plan for further bone treatment.